Work

High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

Year: 2018

Type: article

Abstract: Key Points High NPM1-mutant allele burden at diagnosis is associated with poor clinical outcome in de novo AML. The adverse effect of high NPM1-mutant allele burden is independent of comutations and clinical variables.

Source: Blood

DOI: 10.1182/blood-2018-01-828467

Authors: Sanjay S. Patel, Frank C. Kuo, Christopher J. Gibson, David P. Steensma, Robert J. Soiffer, Edwin P. Alyea, Yi-Bin A. Chen, Amir T. Fathi, Timothy A. Graubert, Andrew M. Brunner, Martha Wadleigh, Richard M. Stone, Daniel J. DeAngelo, Valentina Nardi, Robert P. Hasserjian, Olga K. Weinberg

Institutions: Brigham and Women's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, Boston Children's Hospital

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute

Awards: SPORE in Myeloid Malignancies, Development of Novel Therapeutic Strategies in Human Leukemias

OpenAlex ID: W2803035195

FWCI: 9.354

Cites: 33

Cited by: 88

Related to: 10