Work

Formal [4 + 2] cycloaddition of imines with alkoxyisocoumarins

Year: 2018

Type: article

Abstract: A new preparation of δ-lactams is reported. In the presence of a Lewis acid promoter, alkoxyisocoumarins engage a range of N-aryl and N-alkyl imines to form δ-lactams with a pendent carboalkoxy substituent. A sulfonamide-thiourea catalyst enables the synthesis of these products in moderate to good enantioselectivities.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c8ob01015c

Authors: Claire L. Jarvis, Neyra M. Jemal, Spencer Knapp, Daniel Seidel

Institutions: Rutgers, The State University of New Jersey, University of Florida

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green