Work

Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists

Year: 2018

Type: article

Abstract: This work reports the synthesis and pharmacological and electrophysiological evaluation of new N-methyl-d-aspartic acid receptor (NMDAR) channel blocking antagonists featuring polycyclic scaffolds. Changes in the chemical structure modulate the potency and voltage dependence of inhibition. Two of the new antagonists display properties comparable to those of memantine, a clinically approved NMDAR antagonist.

Source: ACS Chemical Neuroscience

DOI: 10.1021/acschemneuro.8b00154

Authors: Rosana Leiva, Matthew B. Phillips, Andreea L. Turcu, Esther Gratacòs-Batlle, Lara León-García, Francesc X. Sureda, David Soto, Jon W. Johnson, Santiago Vázquez

Institutions: Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, University of Pittsburgh, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat Rovira i Virgili

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministerio de Economía y Competitividad, Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, National Institutes of Health, Secretaría de Estado de Investigación, Desarrollo e Innovación, European Regional Development Fund, National Institute of Mental Health

Awards: G3498886482, G543814419, Permeation, Block, and Gating of NMDA Receptors

OpenAlex ID: W2803317396

FWCI: 0.455

Cites: 57

Cited by: 14

Related to: 10