Work

Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine

Year: 2018

Type: article

Abstract: The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciy405

Authors: Matthew M Ippolito, Jeffrey M Jacobson, Michael M Lederman, Markus Winterberg, Joel Tarning, Theresa A Shapiro, Charles Flexner

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Temple University, Case Western Reserve University, Mahidol University, University of Oxford, Mahidol Oxford Tropical Medicine Research Unit

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Bill and Melinda Gates Foundation, Fisher Center for Alzheimer's Research Foundation, GlaxoSmithKline, Gilead Sciences, Johns Hopkins University, Wellcome Trust, ViiV Healthcare, Mylan, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Janssen Pharmaceuticals

Awards: G3873853564, Case Clinical Trials Unit, G650174051, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, Clinical Pharmacology Training Program, Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)

OpenAlex ID: W2803352346

FWCI: 0.95

Cites: 13

Cited by: 7

Related to: 10