The premature infant gut microbiome during the first 6 weeks of life differs based on gestational maturity at birth
Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The impact of degree of prematurity at birth on premature infant gut microbiota has not been extensively studied in comparison to term infants in large cohorts. METHODS: To determine the effect of gestational age at birth and postnatal exposures on gut bacterial colonization in infants, we analyzed 65 stool samples from 17 premature infants in the neonatal intensive care unit, as well as 13 samples from 13 mostly moderate-to-late premature infants and 189 samples from 176 term infants in the New Hampshire Birth Cohort Study. Gut colonization patterns were determined with 16S rDNA microbiome profiling. RESULTS: Gut bacterial alpha-diversity differed between premature and term infants at 6 weeks of age, after adjusting for exposures (p = 0.027). Alpha-diversity varied between extremely premature (<28 weeks gestation) and very premature infants (≥28 but <32 weeks, p = 0.011), as well as between extremely and moderate-to-late premature infants (≥32 and <37 weeks, p = 0.004). Newborn antibiotic use among premature infants was associated with lower Bifidobacterium and Bacteroides abundance (p = 0.015 and p = 0.041). CONCLUSION: Gestational age at birth and early antibiotic exposure have significant effects on the premature infant gut microbiota.
Source: Pediatric Research
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Funders: U.S. Environmental Protection Agency, March of Dimes Foundation, Hitchcock Foundation, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, U.S. National Library of Medicine, National Center for Research Resources, National Center for Complementary and Integrative Health
Awards: G1271911877, G142613954, G1700080321, G181906898, Renal Function and Disease, Center for Molecular Epidemiology, G2229312748, G2235810168, G2274534733, G2676936577, G2884123220, G2916098388, G2930326278, G3079566642, G3329380511, G4212485709, G527254553, G5474420044, The Role of the Gut Microbiota in Ulcerative Colitis, G7121763757, G7423465331, G766807502, G7833852088, G819391142, G9000002274, G9000068125, G9000072749, G9000092425, G9000114022, G9000134268, G9000155670, G9000187988, G9000267474, Center of Excellence in Environmental Toxicology, A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study, New Hampshire IDeA Network of Biomedical Research Excellence (NH-INBRE), G960423018
OpenAlex ID: W2803609709