Work

Total Synthesis of the Marine Phosphomacrolide, (−)-Enigmazole A, Exploiting Multicomponent Type I Anion Relay Chemistry (ARC) in Conjunction with a Late-Stage Petasis–Ferrier Union/Rearrangement

Year: 2018

Type: article

Abstract: An effective late-stage large-fragment union/rearrangement exploiting the Petasis-Ferrier protocol, in conjunction with multicomponent Type I Anion Relay Chemistry (ARC) to access advanced intermediates, permits completion of a convergent, stereocontrolled total synthesis of the architecturally complex phosphomacrolide (-)-enigmazole A (1).

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.8b00899

Authors: Yanran Ai, Mariya V. Kozytska, Yike Zou, Anton S. Khartulyari, William A. Maio, Amos B. Smith

Institutions: Monell Chemical Senses Center, University of Pennsylvania

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: University of Pennsylvania, National Institutes of Health, National Cancer Institute

Awards: Antitumor Agents: Structure and Synthesis, G1761111181