Work

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

Year: 2018

Type: article

Study design: Observational Study

Abstract: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to intercellular adhesion molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline levels of antibody to the ICAM1-binding PfEMP1 domain, DBLβ3 PF11_0521 , in comparison to four control antigens, including NTS-DBLα and CIDR1 domains from another group A variant and a group B/C variant.

Source: Infection and Immunity

DOI: 10.1128/iai.00485-17

Authors: Sofonias K. Tessema, Digjaya Utama, Olga Chesnokov, Anthony N. Hodder, Clara S. Lin, G. L. Abby Harrison, Jakob S. Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S. Hansen, Andrew V. Oleinikov, Ivo Mueller, Alyssa E. Barry

Institutions: The University of Melbourne, Walter and Eliza Hall Institute of Medical Research, Florida Atlantic University, University of Copenhagen, Copenhagen University Hospital, AIMST University, Technical University of Denmark, Papua New Guinea Institute of Medical Research, Wellcome Sanger Institute, University of Oxford, Institut Pasteur

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Wellcome Trust, Danmarks Frie Forskningsfond, National Institutes of Health, National Health and Medical Research Council, National Institute of Allergy and Infectious Diseases

Awards: Naturally acquired immunity to malaria, Using parasite population genomics to improve understanding of malaria epidemiology, Mapping malaria parasite populations and outbreaks in Papua New Guinea, G63110524, Identification of vaccine candidates against severe malaria

OpenAlex ID: W2803759292

FWCI: 10.25

Cites: 46

Cited by: 54

Related to: 10