Work

Experimental Evolution of Escherichia coli K-12 at High pH and with RpoS Induction

Year: 2018

Type: article

Abstract: in its native habitat encounters high-pH stress such as that of pancreatic secretions. Experimental evolution over 2,000 generations showed selection for mutations in regulatory factors, such as deletion of the phosphate regulator PhoB and mutations that alter the function of the global stress regulator RpoS. RpoS is induced at high pH via multiple mechanisms.

Source: Applied and Environmental Microbiology

DOI: 10.1128/aem.00520-18

Authors: Issam Hamdallah, Nadia Torok, Katarina M. Bischof, Nadim Majdalani, Sriya Chadalavada, Nonto Mdluli, Kaitlin E. Creamer, Michelle Clark, Chase Holdener, Preston J. Basting, Susan Gottesman, Joan L. Slonczewski

Institutions: National Institutes of Health, Kenyon College, National Cancer Institute

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Science Foundation

Award: RUI: Benzoate and pH Stress in Experimental Evolution of Escherichia coli

OpenAlex ID: W2803768945

FWCI: 1.525

Cites: 53

Cited by: 37

Related to: 10