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Context matters: TH2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity

Year: 2018
Type: article
Abstract: Birch (Betula verrucosa) pollen is the main cause of spring pollinosis in the temperate climate zone of the Northern Hemisphere. Approximately 95% of birch pollen–allergic patients are sensitized to Bet v 1, the major birch pollen allergen.1 However, it is not known whether sensitization toward Bet v 1 results from its own intrinsic properties or from immunomodulatory pollen compounds codelivered with the allergen. Therefore, we investigated whether Bet v 1 or the pollen matrix is responsible for the activation of antigen-presenting cells and the subsequent TH2 polarization, relevant in the process of allergic sensitization.
DOI: 10.1016/j.jaci.2018.05.004
Authors: Lorenz Aglas, Stefanie Gilles, Renate Bauer, Sara Huber, Galber R. Araujo, Geoffrey Mueller, Sandra Scheiblhofer, Marie Amisi, Hieu-Hoa Dang, Peter Briza, Barbara Bohle, Jutta Horejs-Hoeck, Claudia Traidl-Hoffmann, Fatima Ferreira
Institutions: University of Salzburg, Helmholtz Munich, CK-CARE, Technical University of Munich, National Institutes of Health, National Institute of Environmental Health Sciences, Medical University of Vienna
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,900
OpenAlex ID: W2803784379
FWCI: 3.57
Cites: 13
Cited by: 43
Related to: 10