Work

A Strategy toward Icetexane Natural Products

Year: 2018

Type: article

Abstract: Icetexane diterpenoids are richly complex polycyclic natural products that have been described with a variety of biological activities. We report here a general synthetic approach toward the 6-7-6 tricyclic core structure of these interesting synthetic targets based on a two-step enolate alkylation and ring-closing metathesis reaction sequence.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201800707

Authors: Daniel J. Moon, Mohammad Al‐Amin, Robert S. Lewis, Kimberly M. Arnold, Glenn P. A. Yap, Jennifer Sims‐Mourtada, William J. Chain

Institutions: University of Delaware, Christiana Care Health System

Language: English

Topic: Synthetic Organic Chemistry Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, University of Delaware, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G1288609621, G1405442584, Discovery of Chemical Probes and Therapeutic Leads, Phase II, Molecular Design of Advanced Biomaterials, CRIF:MU Cryprobe Upgrade of a NMR Spectrometer, Carbonyls to Cancer Therapeutics, Acquisition of a 400 MHz NMR Spectrometer, Molecular Design of Advanced Biomaterials, MRI: Acquisition of a High Resolution Mass Spectrometer for Small Molecule Analysis, Q-Exactive Orbitrap LC-MC/MS System

OpenAlex ID: W2803912572

FWCI: 0.512

Cites: 56

Cited by: 8

Related to: 10