Year: 2014
Type: dissertation
Abstract: Teneurin C-terminal associated peptide (TCAP)-1 is a cleavable bioactive peptide on the carboxy terminus of teneurin proteins. Previous findings indicate that the primary role of TCAP-1 may be to regulate metabolic optimization in the brain by increasing the efficiency of glucose transport and energy utilization. The findings show that TCAP-1 administration in rats results in a 20-30% decrease in plasma glucose levels and an increase in 18F-2-deoxyglucose uptake into the cortex. In vitro, TCAP-1 also induces 3H-deoxyglucose transport into hypothalamic neurons via an insulin-independent manner. This is correlated with an increase in membrane GLUT3 immunoreactivity. A previously deduced pathway by which TCAP-1 signals in vitro was used to establish a link between the MEK-ERK1/2 pathway and glucose uptake as well as a connection between the MEK-ERK1/2 and AMPK pathways. Immunoreactivity studies indicate that the TCAP-1 system exists in muscle and may play a part in skeletal muscle metabolism and physiology.
Source: TSpace (University of Toronto)
Author: Yani Chen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2803932164