Year: 2006
Type: article
Abstract: Heidel e g U i e sit , Ma hei , Ge a .Backgrou d Autoi u e diseases affe t o e o e tha e .Fo e a ple, it has ee esti ated that % of oughl .illio people ho suffe of a autoi u e diso de i the U ited States a e fe ale.The p e ise easo s fo this ge de ias a e u lea , ut se ho o es a d / o se ho o e elated ge es odulate sus epti ilit .Disti t i u e e i o e ts i ales a d fe ales u de lie a of the se diffe e es i autoi u it .These e i o e ts a e esta lished the toki es eleased i u e ells, pa ti ula l T helpe T H l pho tes.Fe ales a e o e likel to de elop a T H espo se do i ated i te leuki -IL-, i te fe o -g IFN-g , a d l photo i afte halle ge ith a i fe tious age t o a tige , e ept du i g p eg a he a T H e i o e t p e ails do i ated IL-, IL-, IL-, IL-a d TGF-.Fu the o e, the deg ee of i u e espo se also diffe s et ee e a d o e .As a d oge s see to e p i a il supp essi e o ellula a d hu o al i u it , i u e espo ses te d to e o e igo ous i fe ales, esulti g i g eate a ti od p odu tio a d i eased ellediated i u it afte i u isatio .The e a e se e al possi le a s i hi h se ho o es ould affe t the i u e s ste .The a odulate T ell e epto sig ali g, e p essio of a ti atio ole ules o T l pho tes a d a tige -p ese ti g ells, t a s iptio o t a slatio of toki e ge es, o l pho te ho i g.
Source: PubMed Central
Author: Wilhelm H Schmitt
Institutions: Heidelberg University, University Medical Centre Mannheim
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2803940416