Environmental and gene therapy approaches to improve glycemic control and promote healthy aging
Year: 2017
Type: article
Abstract: Considering that impaired proximal insulin signaling is linked with diabetes, approaches that enhance glucose disposal independent of insulin signaling are attractive.In vitro data indicate that the E4ORF1 peptide derived from human adenovirus 36 (Ad36) interacts with cells from adipose tissue, skeletal muscle and liver to enhance glucose disposal, independent of proximal insulin signaling.Adipocyte-specific expression of Ad36E4ORF1 improved hyperglycemia in mice.To determine the hepatic interaction of Ad36E4ORF1 in enhancing glycemic control, we expressed E4ORF1 of Ad36 or adenovirus 5, or fluorescent tag alone using recombinant adeno-associated viral vector in the livers of three mouse models.In diabetic db/db or diet induced obesity (DIO) mice, hepatic expression of Ad36E4ORF1, but not Ad5E4ORF1 robustly improved glycemic control.
Author: Travis McMurphy
Institution: The Ohio State University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2803979402