Year: 2018
Type: article
Abstract: BACKGROUND: The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides. It has been proposed that insulin influences natriuretic peptide production. OBJECTIVE: We sought to determine the acute effects of insulin administration on natriuretic peptide concentrations. METHODS: 31 men and women (11 lean, 10 overweight, and 10 obese), ages 30-70 years, without cardiovascular disease or overt diabetes underwent a hyperinsulinemic-euglycemic insulin clamp. Plasma concentrations of N-terminal pro atrial natriuretic peptide (NT-proANP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured at baseline and steady-state (the final 30 minutes of the clamp protocol). RESULTS: From baseline to steady-state, insulin levels increased from a mean level of 9.5 to 176.7 μU/ml (p<0.001). Over this period, circulating NT-proANP concentrations decreased by 9% (-1933 ng/L, p = 0.01). The changes in NT-proANP did not differ between lean, overweight, and obese individuals. Steady-state NT-proANP levels, adjusted for baseline, were lower in individuals with greater insulin resistance, independent of BMI. In contrast to NT-proANP, NT-proBNP levels did not change significantly during the clamp (p = 0.41). CONCLUSION: Insulin administration was associated with a moderate decrease in circulating NT-proANP, but not NT-proBNP. The lowest NT-proANP concentrations were found in insulin-resistant individuals. Further investigations are warranted to elucidate potential mechanisms underlying the effects of insulin on the cardiac hormonal axis.
Source: PLoS ONE
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: U.S. Department of Veterans Affairs, American Heart Association, Vanderbilt University, Vanderbilt University Medical Center, National Institutes of Health, School of Medicine, Vanderbilt University, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1805704937, G2019238319, G2019972998, Vanderbilt O'Brien Mouse Kidney Physiology and Disease Center, G261087380, Microbiome and Dietary Signatures of Cardiometabolic Health, G2683268942, G3143440274, G3272238124, G3724951926, Obesity, salt-sensitivity, and the natriuretic peptides, G5554188327, G5679716143, The Vanderbilt Institute for Clinical and Translational Research (VICTR), G8553641780, G9000041188, G9000052735, G9000088904, Research Training in Diabetes and Endocrinology
OpenAlex ID: W2804110710