An Observational Cohort Study of Clostridium difficile Ribotype 027 and Recurrent Infection
Year: 2018
Type: article
Study design: Observational Study
Abstract: CDI is a major public health issue, with over 400,000 cases per year in the United States alone. Recurrent CDI is common, occurring in approximately one in five individuals after a primary episode. Although interventions exist that could reduce the risk of recurrence, deployment in all patients is limited by cost, invasiveness, and/or an undetermined long-term safety profile. Thus, clinicians need risk stratification tools to properly allocate treatments. Because prior research on clinical predictors has failed to yield a reliable, reproducible, and effective predictive model to assist treatment decisions, accurate biomarkers of recurrence would be of great value. This study tested whether PCR ribotype independently predicted rCDI, and the data build upon prior research in showing that ribotype 027 is associated with rCDI.
Source: mSphere
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,500
Funders: University of Michigan, National Institutes of Health, Michigan Institute for Clinical and Health Research, National Institute on Aging, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, Claude D. Pepper Older Americans Independence Center, University of California San Francisco
Awards: University of Michigan Center for Gastrointestinal Research, G1619971191, G1762620404, G1815451664, Clostridium difficile Cooperative Research Center, G2702201872, G28982667, G3223614423, G467313275, Systems biology of Clostridium difficile infection, Host and Microbial Biomarkers Related to the Development of Complicated Clostridium difficile Infection, Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center), G911021516
OpenAlex ID: W2804230812