Work

Protein kinase A activation: Something new under the sun?

Year: 2018

Type: article

Abstract: The role of autophosphorylation of the type II regulatory subunit in activation of protein kinase A (PKA) has been a longstanding question. In this issue, Isensee et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708053) use antibody tools that selectively recognize phosphorylated RII and the catalytic subunit active site to reexamine PKA holoenzyme activation mechanisms in neurons.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201805011

Authors: F. Donelson Smith, John D. Scott

Institutions: Howard Hughes Medical Institute, University of Washington

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: PKA & PKC Targeting Mechanisms (Program Project), Local Signaling in Diabetic Comorbidities