Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
Year: 2018
Type: article
Abstract: Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT images. We demonstrate our technique by performing an ILM peel in ex vivo eyes using low ICG concentrations and laser powers. These results establish the feasibility of PT-OCT for intraoperative guidance during retinal surgery.
Source: Optics Letters
DOI: 10.1364/ol.43.002470
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: OPTICALLY BASEDRAPIDSCREENING METHOD FOR PROVEN OPTIMAL TREATMENT STRATEGIES BEFORE TREATMENT BEGINS, CAREER: High-throughput Imaging of Drug Response in Tumor Organoids, Optical imaging of pancreas cancer organoids for drug development and personalized treatment, Cellular level optical metabolic imaging to predict drug response in cancer, Core Grant for Vision Research, G6139086250, G674656198, G6821238466, G775588784, G8458336705, G9000011210
OpenAlex ID: W2804316953