Work

Complexities of Viral Mutation Rates

Year: 2018

Type: article

Abstract: Many viruses evolve rapidly. This is due, in part, to their high mutation rates. Mutation rate estimates for over 25 viruses are currently available. Here, we review the population genetics of virus mutation rates. We specifically cover the topics of mutation rate estimation, the forces that drive the evolution of mutation rates, and how the optimal mutation rate can be context-dependent.

Source: Journal of Virology

DOI: 10.1128/jvi.01031-17

Authors: Kayla M. Peck, Adam S. Lauring

Institution: University of Michigan

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Burroughs Wellcome Fund, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G1676709508, Fidelity, robustness, and diversity in RNA virus evolution and pathogenesis, Molecular Mechanisms of Microbial Pathogenesis Training Program