Work

RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice

Year: 2018

Type: article

Abstract: Key Points Expression of RhoA G17V in CD4+ cells results in cellular and humoral autoimmunity. RhoA G17V expression with Tet2 loss induces T-cell lymphomas with features of AITL.

Source: Blood

DOI: 10.1182/blood-2017-11-818617

Authors: Samuel Y. Ng, Leon Brown, Kristen Stevenson, Tiffany deSouza, Jon C. Aster, Abner Louissaint, David M. Weinstock

Institutions: Harvard University, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Brigham and Women's Hospital, Massachusetts General Hospital, Broad Institute

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: European Hematology Association

Award: G5292443543

OpenAlex ID: W2804469756

FWCI: 6.01

Cites: 61

Cited by: 123

Related to: 10