Work

Can genetics resolve what Notch does in HSCs?

Year: 2018

Type: article

Abstract: The effects of Notch signaling in hematopoietic stem and progenitor cells remain controversial. In work presented in this issue of Blood, Duarte et al interfere genetically with the Notch transcriptional complex (NTC) in hematopoiesis and demonstrate that canonical Notch signals are dispensable in primitive hematopoietic progenitors, as well as across the myeloid, erythroid (E), and megakaryocyte (Mk) lineages.(1)

Source: Blood

DOI: 10.1182/blood-2018-02-829069

Authors: Ivan Maillard, Warren S. Pear

Institution: University of Pennsylvania

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: G491642029