Year: 2015
Type: dissertation
Abstract: HOTAIR is induced by estradiol (E2) in a dose dependant manner, because of its estrogen response elements (EREs) [5]. Regulation• HOTAIR recruits de chromatin modifying complexes PRCS and LSD1.It brings them to the promoter of their target genes.• PRC2 H3K27me3 gain of a repressive mark• LSD1 demethylation H3K4 loss of an activating mark Mechanisms of action• HOTAIR incresses its expression in primary breast cancer tissue 2000 folds, and metastasizes to the lung.The retargeting of PRC2 alters the expression of 854 genes, although, is not clearly if HOTAIR levels can serve as diagnostic or prognosis. Breast cancer• HOTAIR can be a good biomarker because:• It has tissue specific expression • It's the effector molecule• Can be easily accessible (body fluids)• It is easily quantifiable [2]
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2279790677