Year: 1999
Type: article
Abstract: Jorenby DE, Leischow SJ, Nides MA, et al. A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med1999 Mar 4; 340 : 685 –91 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Question What is the relative effectiveness of bupropion, a nicotine patch, placebo, and bupropion plus a nicotine patch for smoking cessation? Randomised, double blind, placebo controlled trial with 1 year follow up. 4 centres in the US. 893 people ≥18 years of age (mean age 43 y, 52% women) who weighed ≥100 lb (≥45.4 kg), were motivated to stop smoking, and who smoked ≥15 cigarettes/day. Exclusion criteria included serious physical or psychiatric illness, pregnancy, lactation, and previous nicotine replacement therapy. Follow up was 80%. Patients were allocated to 9 weeks of either sustained release bupropion, 150 mg/day for days 1 to 3 and 300 mg/day for days 4 to 63 (n=244); nicotine patch, 21 mg/day for weeks 2 to 7, 14 mg/day for week 8, and 7 mg/day for week 9 (n=244); or bupropion plus a nicotine patch (n=245); or placebo (n=160). Patients stopped smoking on day 8 and received counselling for 1 year. Self reported point prevalence rate of abstinence in the previous 7 … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DJorenby%26rft.auinit1%253DD.%2BE.%26rft.volume%253D340%26rft.issue%253D9%26rft.spage%253D685%26rft.epage%253D691%26rft.atitle%253DA%2BControlled%2BTrial%2Bof%2BSustained-Release%2BBupropion%252C%2Ba%2BNicotine%2BPatch%252C%2Bor%2BBoth%2Bfor%2BSmoking%2BCessation%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJM199903043400903%26rft_id%253Dinfo%253Apmid%252F10053177%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJM199903043400903&link_type=DOI [3]: /lookup/external-ref?access_num=10053177&link_type=MED&atom=%2Febmental%2F2%2F3%2F74.atom [4]: /lookup/external-ref?access_num=000078955200003&link_type=ISI
Source: Evidence-Based Mental Health
DOI: 10.1136/ebmh.2.3.74
Author: Goutham Rao
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2804645281