Pancreatic cancer risk is modulated by inflammatory potential of diet and ABO genotype: a consortia-based evaluation and replication study
Year: 2018
Type: article
Abstract: Diets with high inflammatory potential are suspected to increase risk for pancreatic cancer (PC). Using pooled analyses, we examined whether this association applies to populations from different geographic regions and population subgroups with varying risks for PC, including variation in ABO blood type. Data from six case-control studies (cases, n = 2414; controls, n = 4528) in the Pancreatic Cancer Case-Control Consortium (PanC4) were analyzed, followed by replication in five nested case-control studies (cases, n = 1268; controls, n = 4215) from the Pancreatic Cancer Cohort Consortium (PanScan). Two polymorphisms in the ABO locus (rs505922 and rs8176746) were used to infer participants' blood types. Dietary questionnaire-derived nutrient/food intake was used to compute energy-adjusted dietary inflammatory index (E-DII®) scores to assess inflammatory potential of diet. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted logistic regression. Higher E-DII scores, reflecting greater inflammatory potential of diet, were associated with increased PC risk in PanC4 [ORQ5 versus Q1=2.20, 95% confidence interval (CI) = 1.85-2.61, Ptrend < 0.0001; ORcontinuous = 1.20, 95% CI = 1.17-1.24], and PanScan (ORQ5 versus Q1 = 1.23, 95% CI = 0.92-1.66, Ptrend = 0.008; ORcontinuous = 1.09, 95% CI = 1.02-1.15). As expected, genotype-derived non-O blood type was associated with increased PC risk in both the PanC4 and PanScan studies. Stratified analyses of associations between E-DII quintiles and PC by genotype-derived ABO blood type did not show interaction by blood type (Pinteraction = 0.10 in PanC4 and Pinteraction=0.13 in PanScan). The results show that consuming a pro-inflammatory diet and carrying non-O blood type are each individually, but not interactively, associated with increased PC risk.
Source: Carcinogenesis
Authors: Samuel O Antwi, William R Bamlet, Katrina S Pedersen, Kari G Chaffee, Harvey A Risch, Nitin Shivappa, Susan E Steck, Kristin E Anderson, Paige M Bracci, Jerry Polesel, Diego Serraino, Carlo La Vecchia, Cristina Bosetti, Donghui Li, Ann L Oberg, Alan A Arslan, Demetrius Albanes, Eric J Duell, Inge Huybrechts, Laufey T Amundadottir, Robert Hoover, Satu Mannisto, Stephen J Chanock, Wei Zheng, Xiao-Ou Shu, Magdalena Stepien, Federico Canzian, Bas Bueno-de-Mesquita, José Ramon Quirós, Anne Zeleniuch-Jacquotte, Fiona Bruinsma, Roger L Milne, Graham G Giles, James R Hébert, Rachael Z Stolzenberg-Solomon, Gloria M Petersen
Institutions: Mayo Clinic, Washington University in St. Louis, Yale University, University of South Carolina, University of Minnesota, University of California, San Francisco, Centro di Riferimento Oncologico, University of Milan, Mario Negri Institute for Pharmacological Research, The University of Texas MD Anderson Cancer Center, New York University, National Institutes of Health, Division of Cancer Epidemiology and Genetics, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, World Health Organization, Centre international de recherche sur le cancer, Finnish Institute for Health and Welfare, Vanderbilt University, Vanderbilt-Ingram Cancer Center, German Cancer Research Center, University of Malaya, Imperial College London, Gobierno del Principado de Asturias, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, The University of Melbourne, Cancer Council Victoria
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Mayo Clinic, World Health Organization, California Department of Public Health, Yale University, University of Minnesota, Henry Ford Health System, University of Pittsburgh, Georgetown University, Deutsches Krebsforschungszentrum, Wellcome Trust, York University, Cancer Research UK, British Heart Foundation, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Ligue Contre le Cancer, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Mutuelle Générale de l'Education Nationale, National Institutes of Health, University of California, Los Angeles, U.S. Public Health Service, University of Texas MD Anderson Cancer Center, University of California, San Francisco, University of Colorado Denver, National Institute on Aging, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences
Awards: G1060151506, G1149205094, G1313918728, G148522456, FOLLOW UP OF THE ALPHA TOCOPHEROL, BETA CAROTENE LUNG, G1655353241, G1732728960, G1734361364, G1746122051, G1768873342, Prospective Cohort Collaborative in Pancreatic Cancer Epidemiology & Pathogenesis, G1883190377, G1948998734, G1963369394, G2075094911, G2099427675, Case-Control Study of Pancreas Cancer Etiologic Factors, G2142066811, G216524704, G2176833112, G2348368848, G2638876628, G2742033589, G2787837681, FOLLOW-UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY , G296004024, MTHFR POLYMORPHISMS IN PANCREATIC CANCER IN SF BAY AREA, Validation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci (Study), G3312934439, U S-FINLAND STUDIES OF NUTRITION AND CANCER, G3695342494, G3785857135, The NYU Women's Health Study, Vitamin D, Related Genes and Breast Cancer Risk, G4225304566, Molecular Epidemiology of Pancreatic Cancer, G5070257806, G508346776, G5099237660, G5108308032, G5271308498, G5317903265, G5431779508, G5834180306, G601631622, G6048920368, G6124801312, G6238412670, G6242678165, G6386128873, G6388137593, G650037044, G6522129823, G7238814555, G756236474, G7629993686, CASE-CONTROL STUDY--PANCREATIC CANCER &AROMATIC AMINES, G815598048, G9000056458, G9000062327, G9000088907, G9000146046, G9000166794, G9000184592, G9000191336, G9000194858, G9000244873, G9000307018
OpenAlex ID: W2804686871