Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity
Year: 2018
Type: article
Study design: Observational Study
Abstract: AIM OF THE STUDY: The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population. METHODS: We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood. Serum FGF21 was measured during the first and third trimesters. Placentas were collected at delivery. RESULTS: Maternal FGF21 concentrations were positively correlated with body mass index and adiposity, but not lean mass or glucose homeostasis. FGF21 concentrations significantly increased from the first to third trimester of pregnancy (0.105 vs. 0.256 ng/mL, p < 0.0001). Changes in FGF21 concentrations across pregnancy were not associated with changes in body weight or composition but inversely with the change in fasting glucose. FGF21 mRNA levels in placenta were very low and do not likely contribute to FGF21 in the maternal circulation. CONCLUSIONS: FGF21 increases throughout pregnancy in our healthy cohort with overweight and obesity, independent of the placenta, and does not appear to be sensing the changes in energy balance (reflected in the change in maternal energy stores), but changes in macronutrient status. Thus, we propose FGF21 may be a potential signal of maternal nutrient status in pregnancy.
Source: Endocrine Research
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium, Preventing excessive gestational weight gain in obese women, Pregnancy and EARly Lifestyle improvement Study (PEARLS), Maternal-Offspring Metabolics: Family Intervention Trial (MOMFIT), Weight Management in Obese Pregnant Underserved African American Women, Role of FGF21 in Protein Leverage and Placenta Function during Pregnancy, Expecting Success: Personalized management of body weight during pregnancy, Determinants of gestational weight gain in obese pregnant women, Lifestyle Interventions in Overweight and Obese Pregnant Women, Louisiana Clinical and Translational Science Center
OpenAlex ID: W2804713019