Work

ER stress and unfolded protein response in ocular health and disease

Year: 2018

Type: review

Abstract: The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme.

Source: FEBS Journal

DOI: 10.1111/febs.14522

Authors: Heike Kroeger, Wei‐Chieh Chiang, Julia Felden, Amanda Nguyen, Jonathan H. Lin

Institutions: University of California San Diego, University of Tübingen, VA San Diego Healthcare System

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Eye Institute, National Institute of Neurological Disorders and Stroke