Year: 2018
Type: article
Abstract: Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur's rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.
Authors: Pedro J. Esteves, Joana Abrantes, Hanna-Mari Baldauf, Lbachir BenMohamed, Yuxing Chen, Neil Christensen, Javier González-Gallego, Lorenzo Giacani, Jiafen Hu, Gilla Kaplan, Oliver T. Keppler, Katherine L. Knight, Xiang-Peng Kong, Dennis K. Lanning, Jacques Le Pendu, Ana Lemos de Matos, Jia Liu, Shuying Liu, Ana M. Lopes, Shan Lu, Sheila Lukehart, Yukari C. Manabe, Fabiana Neves, Grant McFadden, Ruimin Pan, Xuwen Peng, Patricia de Sousa-Pereira, Ana Pinheiro, Masmudur Rahman, Natalie Ruvoën-Clouet, Selvakumar Subbian, Maria Jesús Tuñón, Wessel van der Loo, Michael Vaine, Laura E. Via, Shixia Wang, Rose Mage
Institutions: Universidade do Porto, Cooperativa de Ensino Superior Politécnico e Universitário, Centro de Investigação em Biodiversidade e Recursos Genéticos, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, University of California, Irvine, University of Massachusetts Chan Medical School, Pennsylvania State University, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Universidad de León, University of Washington, Gates Foundation, Loyola University Chicago, New York University, Inserm, Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers, Université de Nantes, Université d'Angers, Nantes Université, Arizona State University, University of Arkansas for Medical Sciences, Instituto de Ciências Biomédicas Albel Salazar, Johns Hopkins University, Johns Hopkins Medicine, Rutgers, The State University of New Jersey, Rutgers Health, Rutgers New Jersey Medical School, National Institutes of Health, University of Cape Town, National Institute of Allergy and Infectious Diseases, Institute of Infectious Disease and Molecular Medicine
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,490
Funders: Bill and Melinda Gates Foundation, Rivkin Center for Ovarian Cancer, Institut National de la Santé et de la Recherche Médicale, Ludwig-Maximilians-Universität München, National Institutes of Health, Fundação para a Ciência e a Tecnologia, Instituto de Salud Carlos III, National Eye Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: G1090578777, GENETIC CHARACTERIZATION OF INTERLEUKIN GENES WITH RELEVANT ROLES IN IMPORTANT BIOLOGICAL FUNCTIONS IN LAGOMORPHS, G1472214824, Center for Microbial Pathogenesis and Host Inflammatory Responses, G2650997987, G2671146130, G2829553145, University of Pittsburgh - to develop whole body imaging technologies to shorten the duration of chemotherapy for TB., Impact of Iron Supplementation on the Latency and Reactivation of Tuberculosis, G3148859476, G3399638015, G358322560, Induction of neutralizing antibodies targeting CD4 binding region of HIV-1 Env, Institute for Clinical and Translational Science, G4129836948, G416035351, G4165595082, G418649935, G4707659958, G6306898267, G632199118, Insights into the immunoglobulins in leporids: an evolutionary and functional approach., G6855257783, G7537039131, G7554052188, A DEFINIR DURANTE O PRIMEIRO ANO DO PROGRAMA DOUTORAL, G8114827453, G9000019252, G9000044662, G9000101008, G9000273926, G9000285332
OpenAlex ID: W2805031563