Year: 2018
Type: editorial
Abstract: In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on genes and thus simplify the results. This Commentary is a plea from one member of the Mobile DNA community to all gene-centric researchers: please do not ignore the repetitive fraction of the genome . Please stop narrowing your findings by only analyzing a minority of the genome, and instead broaden your analyses to include the rich biology of repetitive and mobile DNA. In this article, I present four arguments supporting a case for retaining repetitive DNA in your genome-wide analysis.
Source: Mobile DNA
Author: R. Keith Slotkin
Institution: The Ohio State University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,290
Funder: National Science Foundation
Awards: CAREER: The Mechanism and Genome-Wide Regulation of Genes and Transposable Elements by Epigenetically Active Small Interfering RNAs, Genetic and Epigenetic Regulation of Gametophyte Development and Transposon Expression in Maize, Re-evaluating Mechanisms of RNA-mediated Initiation of Transposable Element Silencing in Plants
OpenAlex ID: W2805084391