Get started
Work

BP180 dysfunction triggers spontaneous skin inflammation in mice

Year: 2018
Type: article
Abstract: ) developed spontaneous skin inflammatory disease, characterized by severe itch, defective skin barrier, infiltrating immune cells, elevated serum IgE levels, and increased expression of thymic stromal lymphopoietin (TSLP). Severe itch is independent of adaptive immunity and histamine, but dependent on increased expression of TSLP by keratinocytes. In addition, a high TSLP expression is detected in BP patients. Our data provide direct evidence showing that BP180 regulates skin inflammation independently of adaptive immunity, and BP180 dysfunction leads to a TSLP-mediated itch. The newly developed mouse strain could be a model for elucidation of disease mechanisms and development of novel therapeutic strategies for skin inflammation and BP180-related skin conditions.
DOI: 10.1073/pnas.1721805115
Authors: Yang Zhang, Bin-Jin Hwang, Zhen Liu, Ning Li, Kendall Lough, Scott E. Williams, Jinbo Chen, Susan W. Burette, Luis A. Diaz, Maureen A. Su, Shengxiang Xiao, Zhi Liu
Institutions: University of North Carolina at Chapel Hill, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, UNC Lineberger Comprehensive Cancer Center, Wuhan No.1 Hospital, Huazhong University of Science and Technology
Language: English
Subfield: Dermatology
Field: Medicine
Open Access status: green
OpenAlex ID: W2805446727
FWCI: 5.679
Cites: 45
Cited by: 45
Related to: 10