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Impact of a Multidomain Intensive Lifestyle Intervention on Complaints About Memory, Problem-Solving, and Decision-Making Abilities: The Action for Health in Diabetes Randomized Controlled Clinical Trial

Year: 2018
Type: article
Abstract: Background: Lifestyle interventions to reduce weight and increase activity may preserve higher-order cognitive abilities in overweight/obese adults with type 2 diabetes (T2D). Methods: Adults (N = 5,084) with T2D who enrolled in a randomized clinical trial of a 10-year intensive lifestyle intervention (ILI) compared with diabetes support and education were queried at baseline and repeatedly during follow-up for complaints about difficulties in memory, problem-solving, and decision-making abilities. Results: For those without baseline complaints, assignment to ILI was associated with lower odds that complaints would emerge during follow-up for decision-making ability (odds ratio [OR]=0.851, [95% CI, 0.748,0.967], p=0.014), and, among individuals who were not obese, lower odds that complaints would emerge about problem-solving ability (OR=0.694 [0.510,0.946]). No cognitive benefits from ILI were seen for individuals with baseline complaints about cognitive abilities. ILI may have exacerbated the severity of complaints about problem-solving ability during follow-up among individuals with baseline complaints and cardiovascular disease (OR=2.949 [1.378,6.311]). Conclusions: A long-term multidomain ILI may reduce the likelihood that complaints about difficulties in higher-order cognitive abilities will emerge in T2D adults without pre-existing complaints. Among those with pre-existing complaints, the ILI did not prevent increases in complaint severity.
DOI: 10.1093/gerona/gly124
Authors: Mark A Espeland, Gareth R Dutton, Rebecca H Neiberg, Owen Carmichael, Kathleen M Hayden, Karen C Johnson, Robert W Jeffery, Laura D Baker, Delilah R Cook, Dalane W Kitzman, Stephen R Rapp
Institutions: Wake Forest University Health Sciences, Wake Forest University, University of Alabama at Birmingham, Pennington Biomedical Research Center, University of Tennessee Health Science Center, University of Minnesota
Language: English
Field: Medicine
Open Access status: green
Awards: G1153142239, G1442900148, G1559150778, G1561916549, G219693323, G2247787434, G2519210884, G3033840998, G3085877500, 05/16 Action for Health in Diabetes Extension Study - Research Project, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, G3728863030, University of Pittsburgh Clinical and Translational Science Institute, Exercise Intolerance in Older HFPEF Patients, G4623107666, G474757791, 09/16 Action for Health in Diabetes Extension Study Research Project, 08/16 Action for Health in Diabetes Extension Study Research Project, 07/16 Action for Health in Diabetes Extension Study Research Project, G5800301348, G7244940528, G7376939847, 12/16 Action for Health in Diabetes Extension Study Research Project, G9000043935, G9000087769, G9000111718, G9000115744, G9000119805, G9000127204, G9000160430, G9000194531, G9000203865, G9000245686, G9000246354, G9000285666
OpenAlex ID: W2805670832
FWCI: 1.799
Cites: 43
Cited by: 16
Related to: 10