Work

Maximizing the impact of microphysiological systems with in vitro – in vivo translation

Year: 2018

Type: article

Abstract: Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here, we first summarize why MPSs are needed in pharmaceutical development, and examine how MPS technologies can be utilized to improve preclinical efforts. We then provide the perspective that the full impact of MPS technologies will be realized only when robust approaches for in vitro-in vivo (MPS-to-human) translation are developed and utilized, and explain how the burgeoning field of quantitative systems pharmacology (QSP) can fill that need.

Source: Lab on a Chip

DOI: 10.1039/c8lc00039e

Authors: Murat Cirit, Cynthia L. Stokes

Institution: Massachusetts Institute of Technology

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Center for Advancing Translational Sciences