Work

Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus

Year: 2018

Type: article

Abstract: F901318 (olorofim) is a novel antifungal drug that is highly active against Aspergillus species. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00231-18

Authors: Saskia du Pré, Nicola Beckmann, Mariana Cruz Almeida, Graham E. M. Sibley, Derek Law, Alexandra C. Brand, Mike Birch, Nick D. Read, Jason D. Oliver

Institutions: University of Manchester, F2G (United Kingdom), University of Aberdeen, MRC Centre for Medical Mycology

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Manchester, European Commission, University of Aberdeen, Medical Research Council Centre for Medical Mycology, Medical Research Council, FP7 People: Marie-Curie Actions

Awards: MRC Centre for Medical Mycology, G1666550810, G3088556965, Sensing and integration of signals governing cell polarity and tropism in fungi, G7032896584, G7138861111, G7607068665

OpenAlex ID: W2805839259

FWCI: 10.12

Cites: 34

Cited by: 114

Related to: 10