Work

Development of a Three‐Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

Year: 2018

Type: article

Abstract: This unit describes a protocol for generation of lung organoids. A lung organoid is a 3D cell/hydrogel composite that resembles the morphology and cellular composition of the human distal lung. These tissue-engineered constructs provide an in vitro model of human lung and are best suited for disease modeling applications. The organoid generation methodology is flexible, allowing for easy scalability in the number of organoids produced and in the ability to accommodate a wide range of cell types. © 2018 by John Wiley & Sons, Inc.

Source: Current Protocols in Stem Cell Biology

DOI: 10.1002/cpsc.56

Authors: Dan C. Wilkinson, Michael Mellody, Luisa K. Meneses, Ashley C. Hope, Bruce Dunn, Brigitte N. Gomperts

Institutions: University of California, Los Angeles, Mattel Children's Hospital, UCLA Jonsson Comprehensive Cancer Center

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Cancer Institute, National Institute of General Medical Sciences