Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort
Year: 2018
Type: article
Abstract: BACKGROUND: We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS: Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer's Disease Neuroimaging Initiative), a longitudinal cohort study. RESULTS: Sleep disturbance was not associated with decline in memory, executive function, or global cognition. The presence of sleep disturbance did not significantly increase the risk of diagnostic conversion in CN, early MCI, or late MCI participants. CONCLUSION: This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline.
DOI: 10.1159/000488671
Authors: Adam P. Mecca, Hannah R. Michalak, Julia W. McDonald, Emily C. Kemp, Erika A. Pugh, Melinda L. Becker, Marcia C. Mecca, Christopher H. van Dyck, The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Institutions: Yale University, VA Connecticut Healthcare System
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G104586243, G1120619015, G2515091901, G2957681590, G5351607658, Alzheimer's Disease Neuroimaging Initiative, Investigation of molecular changes in mGluR5 and SV2A to study synaptic alterations in Alzheimer's disease using PET., Yale Alzheimer Disease Research Center, Alzheimer's Disease Neuroimaging Initiative (ADNI4)
OpenAlex ID: W2806091940