Work

Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report

Year: 2018

Type: article

Abstract: BACKGROUND: Synchronous squamous cell carcinoma of the head and neck (HNSCC) and non-Hodgkin's lymphoma is a rare clinical scenario. It is unknown whether the R-CHOP chemotherapy for lymphoma would also be active against HNSCC. Herein, we present such a case and a review of the literature. CASE PRESENTATION: squamous cell carcinoma was found incidentally on staging CT. R-CHOP chemotherapy was initiated. After 3 cycles of R-CHOP the lymphoma had a complete metabolic response and, unexpectedly, the HNSCC also demonstrated excellent response. The patient received another 3 cycles followed by radiation to the HNSCC and to date is in remission for both cancers. CONCLUSIONS: This case highlights the exquisite sensitivity of HPV-related HNSCC, which should be taken into consideration in treatment prioritization of a concurrent diagnosis of a second cancer.

Source: Cancers of the Head & Neck

DOI: 10.1186/s41199-018-0028-6

Authors: Ting Martin Ma, Hyunseok Kang, Steven P. Rowe, Ana P. Kiess

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,290