Parameterized Joint Reconstruction of the Initial Pressure and Sound Speed Distributions for Photoacoustic Computed Tomography
Year: 2018
Type: article
Abstract: Accurate estimation of the initial pressure distribution in photoacoustic computed tomography (PACT) depends on knowledge of the sound speed distribution. However, the sound speed distribution is typically unknown. Further, the initial pressure and sound speed distributions cannot both, in general, be stably recovered from PACT measurements alone. In this work, a joint reconstruction (JR) method for the initial pressure distribution and a low-dimensional parameterized model of the sound speed distribution is proposed. By employing a priori information about the structure of the sound speed distribution, both the initial pressure and sound speed can be accurately recovered. The JR problem is solved by use of a proximal optimization method that allows constraints and nonsmooth regularization functions for the initial pressure distribution. The gradients of the cost function with respect to the initial pressure and sound speed distributions are calculated by use of an adjoint state method that has the same per-iteration computational cost as calculating the gradient with respect to the initial pressure distribution alone. This approach is evaluated through two-dimensional computer-simulation studies for a small animal imaging model and by application to experimental in vivo measurements of a mouse.
Source: SIAM Journal on Imaging Sciences
DOI: 10.1137/17m1153649
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: G1148754291, G1704182483, WHOLE-BODY SMALL-ANIMAL PHOTOACOUSTIC-ULTRASONIC COMPUTED TOMOGRAPHY, G382787260, HIGH PERFORMANCE BIOMEDICAL IMAGING COMPUTER RESOURCES, OP: Collaborative Research: Development of Advanced Image Reconstruction Methods for Pre-Clinical Applications of Photoacoustic Computed Tomography
OpenAlex ID: W2806174965