Year: 2018
Type: article
Abstract: The NLRC4 inflammasome requires IRF8-dependent production of NAIPs – Inflammasomes orchestrate cellular responses to pathogen- or danger-associated molecular patterns by controlling the activation of caspase-1. Inflammasome activation results in enzymatically active caspase-1, which mediates the maturation and release of the pro-inflammatory cytokines IL-1β and IL-18 and induces a form of inflammatory cell death termed pyroptosis. The NLRC4 inflammasome is crucial for protection against infection (...)
Source: Cell Stress
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,283
Awards: G137859075, Role of IL-1alpha signaling in inflammatory diseases and host defense, G3831755428, G4358640472, G5372223083, Inflammatory Caspases in Innate Immunity and Inflammation, G8167955467, G9000196776, G9000290205, Inflammatory Caspases in Innate Immunity and Inflammation, Innate immune signaling and stress response
OpenAlex ID: W2806483119