Work

RNA ‐protein interactions in an unstructured context

Year: 2018

Type: review

Abstract: Despite their importance, our understanding of noncovalent RNA-protein interactions is incomplete. This especially concerns the binding between RNA and unstructured protein regions, a widespread class of such interactions. Here, we review the recent experimental and computational work on RNA-protein interactions in an unstructured context with a particular focus on how such interactions may be shaped by the intrinsic interaction affinities between individual nucleobases and protein side chains. Specifically, we articulate the claim that the universal genetic code reflects the binding specificity between nucleobases and protein side chains and that, in turn, the code may be seen as the Rosetta stone for understanding RNA-protein interactions in general.

Source: FEBS Letters

DOI: 10.1002/1873-3468.13116

Authors: Bojan Zagrovic, Lukas Bartonek, Anton A. Polyansky

Institutions: University of Vienna, Max Perutz Labs, Russian Academy of Sciences, Institute of Bioorganic Chemistry

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,980

Funders: Austrian Science Fund, European Research Council, FP7 Ideas: European Research Council