Year: 2018
Type: review
Abstract: BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. MAJOR CONCLUSIONS: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.
Source: Molecular Metabolism
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,270
Awards: G128250742, G1962294701, G2445166129, G2980772895, Formation and maturation of endocrine pancreas progenitors, Repurposing estrogens to improve pancreatic islet transplantation, G4181531677, G447170978, G4631477635, Interrupting the Vicious Cycle of Obesity and Metabolic Syndrome, Role of SerpinB1 in beta cell growth, G6558746943, Redox Regulation of Anti-Viral Responses in Type 1 Diabetes, G7319041433, G7980274559, G8293097804, G9000149510, Diabetes Research Center, Genetic and molecular architecture of sex-specific drug response in human islets, Role of IGF-1 and insulin receptors beta-cell survival, UAB Diabetes Research Center
OpenAlex ID: W2806507802