What Have We Learned from Expedition III and EPOCH Trials? Perspective of the CTAD Task Force
Year: 2018
Type: article
Abstract: Although the results were disappointing from two recent clinical trials of amyloid-targeting drugs in mild-to-moderate AD, the trials provided information that will be important for future studies, according to the EU-US CTAD Task Force, which met in November 2017 to discuss the EXPEDITION3 and EPOCH trials. These trials tested two of the predominant drug development strategies for AD: amyloid immunotherapy and BACE inhibition in populations largely composed of mild AD dementia patients. The results of these trials support the emerging consensus that effective amyloid-targeted treatment will require intervention in early, even pre-symptomatic stages of the disease. Further, the Task Force suggested that a refinement of the amyloid hypothesis may be needed and that other hypotheses should be more fully explored. In addition, they called for improved biomarkers and other outcome assessments to detect the earliest changes in the development of AD.
Institutions: University of Southern California, Eli Lilly (United States), Merck & Co., Inc., Rahway, NJ, USA (United States), Brown University, CHDI Foundation, Alzheimer's Association, Brigham and Women's Hospital, Harvard University, Roche (Switzerland), Amsterdam UMC Location Vrije Universiteit Amsterdam, Washington University in St. Louis, University of California, San Francisco, Inserm, Centre Hospitalier Universitaire de Toulouse
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,060
OpenAlex ID: W2806599292