A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis
Year: 2018
Type: article
Abstract: Development and cancer share a variety of functional traits such as EMT, cell migration, angiogenesis, and tissue remodeling. In addition, many cellular signaling pathways are noted to coordinate developmental processes and facilitate aspects of tumor progression. The Forkhead box superfamily of transcription factors consists of a highly conserved DNA binding domain, which binds to specific DNA sequences and play significant roles during adult tissue homoeostasis and embryogenesis including development, differentiation, metabolism, proliferation, apoptosis, migration, and invasion. Interestingly, various studies have implicated the role of key Fox family members such as FOXP, FOXO, and FOXA during cancer initiation and metastases. FOXI3, a member of the Forkhead family affects embryogenesis, development, and bone remodeling; however, no studies have reported a role in cancer. In this review, we summarize the role of FOXI3 in embryogenesis and bone development and discuss its potential involvement in cancer progression with a focus on the bone metastasis. Moreover, we hypothesize possible mechanisms underlying the role of FOXI3 in the development of solid tumor bone metastasis.
Authors: Angana Mukherjee, Daniel P. Hollern, Oluwasina G. Williams, Tyeler S. Rayburn, William A. Byrd, Clayton Yates, Jacqueline D. Jones
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G2539917819, BIOMARKERS IN THE DETECTION OF PROSTATE CANCER IN AFRICAN AMERICANS, Transcriptional Regulation of Breast Cancer Metastasis within the Tumor Microenvi, G4119534169, CENTER FOR BIOMEDICAL RESEARCH, G5850682332, G7055404640, G7286121602, CENTER FOR BIOMEDICAL RESEARCH, G9000154432, 2/3 Morehouse School of Medicine/Tuskegee University/ University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership, 1/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership, 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership
OpenAlex ID: W2807916021