Year: 2018
Type: article
Abstract: The macaque models of HIV-1 infection have been a cornerstone of research on transmission, pathogenesis, and prevention. In particular, the infection of macaques with chimeric simian/HIV-1 viruses (SHIVs) is central to the vaccine development pipeline because SHIVs encode the key target of HIV-1-neutralizing antibodies, the HIV-1 envelope (env) protein. In this review, we highlight some of the recent studies that have improved our understanding of the CD4-HIV-1 env interaction, which are crucial for development of SHIV/macaque models of HIV-1 infection.
Authors: Amit Sharma, Julie Overbaugh
Institutions: Fred Hutch Cancer Center, The Ohio State University
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2807983529