Year: 2018
Type: dissertation
Abstract: The global incidence of allergic reaction has been rising for years, especially within westernised urban areas. There is evidence that the interaction between pollen grains, environmental pollution and meteorological change is increasing the allergenicity of the pollen grain and consequently, increasing the misery of hay fever sufferers. Laboratory experiments have shown that the interaction of pollen with atmospheric oxidants such as ozone and nitrogen dioxide (\\(NO_2\\)) can alter protein molecules that are present within the pollen grains via post-translational modification of the protein. \n \nWithin the laboratory, birch pollen was exposed to atmospherically relevant exposures of gas phase \\(NO_2\\) and ozone under a range of environmentally relevant conditions (temperature and relative humidity RH). The effects of the exposures on the biochemistry of the pollen grains were probed using proteomic approach. The morphological changes of unexposed and exposed pollen samples to RH, rainwater and \\(NO_2\\), where observed under fluorescence microscopy and scanning electron microscope. The discoveries suggest that interaction between gas pollutants and pollen do exist and cause protein specific modifications; nitration. \n \nDetailed analysis of London Ambulance data compared to London temperature data is presented. The relationships established will allow for prediction of likely changes in ambulance demand (and illness types) that will be caused by seasonal temperature changes, increased frequency and intensity of extreme weather events, due to climate change, in the future. \n \nThe study applied statistical analyses to examine short-term associations between birch pollen count with allergic related illnesses recorded in the London Ambulance data, temperature and \\(NO_2\\). \n
Author: Marliyyah Abdullahi Mahmood
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2808105300