Work

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA

Year: 2018

Type: article

Abstract: Virulence of Yersinia pestis in mammals requires the type III secretion system, which delivers seven effector proteins into the cytoplasm of host cells to undermine immune responses. All seven of these effectors are conserved across Y. pestis strains, but three, YopJ, YopT, and YpkA, are apparently dispensable for virulence.

Source: Infection and Immunity

DOI: 10.1128/iai.00318-18

Authors: Samantha G. Palace, Megan K. Proulx, Rose L. Szabady, Jon D. Goguen

Institution: University of Massachusetts Chan Medical School

Language: English

Topic: Yersinia bacterium, plague, ectoparasites research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Massachusetts, National Institutes of Health, University of Massachusetts Medical School, National Institute of Allergy and Infectious Diseases