Work

Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor

Year: 2018

Type: article

Abstract: IspF action and inhibition, open new perspectives for designing inhibitors of this important drug target, and demonstrate the applicability and value of the native ESI-MS approach for deep analysis of complex biomolecular binding equilibria.

Source: Chemical Science

DOI: 10.1039/c8sc00814k

Authors: Katharina Root, Konstantin Barylyuk, Anatol Schwab, Jonas Thelemann, Boris Illarionov, Julie G. Geist, Tobias Gräwert, Adelbert Bacher, Markus Fischer, François Diederich, Renato Zenobi

Institutions: ETH Zurich, Universität Hamburg, Technical University of Munich

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Eidgenössische Technische Hochschule Zürich

Award: Soft ionization mass spectrometry for studying noncovalent interactions

OpenAlex ID: W2808193337

FWCI: 0.756

Cites: 58

Cited by: 13

Related to: 10