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Heterogeneity of Treatment Effect by Baseline Risk in a Trial of Balanced Crystalloids versus Saline

Year: 2018
Type: article
Abstract: from patients with non-PH IPF in a cohort study (8).This may be a result of the absence of severe PH in these patients, or because of differences in the mechanisms driving PH in IPF versus PAH.We conclude that nintedanib shows disadvantageous effects in PAH, and future investigations are needed to reveal the precise underlying mechanisms.Moreover, the effect of this agent on pulmonary hemodynamics in patients with IPF and severe accompanying PH should be investigated in future studies.
DOI: 10.1164/rccm.201804-0680le
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: green
Funders: National Institutes of Health, Secretaría de Ciencia y Técnica, Universidad de Buenos Aires, Sistema Nacional de Investigadores, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: The Vanderbilt Emergency Care Research Training Program, G5228231575, The Vanderbilt Institute for Clinical and Translational Research (VICTR), Clinical and Translational Training Program in Pulmonary Medicine, Vanderbilt Institute for Clinical and Translational Research (VICTR), Childhood Infections Research Program
OpenAlex ID: W2808226132
FWCI: 1.819
Cites: 6
Cited by: 12
Related to: 10