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Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression

Year: 2018
Type: article
Abstract: Our results showed that even though RSV exhibits promiscuous binding, its inhibitory effect on cell migration can be mechanistically understood. First, the presence of 4'-hydroxystilbene within the RSV structure is essential for this activity. Second, it inhibits cell migration through epigenetically based downregulation of FAK expression. Taken together, we propose that CPAT might also be adapted to delineate the specific function of other natural products (NPs) that exhibit binding promiscuity.
Source: Theranostics
DOI: 10.7150/thno.24336
Authors: Xiao Chen, Wei Li, Chengchao Xu, Jie Wang, Bo Zhu, Qilai Huang, Dianhua Chen, Jianfei Sheng, Yong Zou, Yew Mun Lee, Renxiang Tan, Pingping Shen, Yin Kwan Wong, Qingsong Lin, Jigang Wang, Zichun Hua
Institutions: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, National University of Singapore, China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, Sun Yat-sen University
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W2808295228
FWCI: 0.938
Cites: 54
Cited by: 26
Related to: 10