Differential Effects of Estradiol and Progesterone on Cardiovascular Risk Factors in Postmenopausal Women
Year: 2018
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Controlled, blinded studies of sex-hormone replacement in postmenopausal women using natural estradiol (E2) and native progesterone (P) are few. To delineate the effect of E2 alone or with P on lipids and inflammatory markers. A placebo-controlled, double-masked, prospectively randomized study of 40 healthy, postmenopausal volunteers assigned to four treatment groups: placebo, intramuscular E2, and/or micronized oral P for 23 (±2) days. Treatment with E2 alone compared with placebo lowered total cholesterol (TC; P = 0.006), non–high-density lipoprotein cholesterol (nonHDL-C; P = 0.004), low-density lipoprotein cholesterol (LDL-C; P = 0.012), and apolipoprotein B (Apo B; P = 0.02) levels, and raised HDL-C levels (P = 0.03 vs the 3 other groups). Conversely, addition of P to E2 reduced HDL-C levels (P = 0.015). Triglyceride concentrations manifested no effect on E2 or P. High-sensitivity C-reactive protein (hsCRP) level was highest in women with E2 and P replacement (P = 0.018 vs placebo). Leptin and IL-6 concentrations did not vary. P treatment decreased adiponectin levels (P = 0.019). Serum E2 levels correlated linearly with TC, LDL-C, nonHDL-C, Apo B (all negatively), and SHBG (positively) concentrations. P level correlated negatively with TC (P = 0.029), HDL-C (P = 0.002), and adiponectin (P = 0.002) levels. In this study, there were individual and interactive effects of E2 and P on key lipids in postmenopausal individuals.
Source: Journal of the Endocrine Society
Institutions: Leiden University Medical Center, Mayo Clinic
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,255
Awards: Minnesota Obesity Center, G219020131, Aging Systems in Geriatrics: the Male Gonadal Axis, Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in Women, Mayo Clinic Center for Clinical and Translational Science (CCaTS), G3165795938, Actions of Testosterone on the Aging Male GH Axis, Mayo Clinic Center for Clinical and Translational Science (CCaTS)
OpenAlex ID: W2808447723