Cessation of Cigarette Smoking and the Impact on Cancer Incidence in Human Immunodeficiency Virus–infected Persons: The Data Collection on Adverse Events of Anti-HIV Drugs Study
Year: 2018
Type: article
Abstract: Background: Cancers are a major source of morbidity and mortality for human immunodeficiency virus (HIV)-infected persons, but the clinical benefits of smoking cessation are unknown. Methods: Participants were followed from 1 January 2004 until first cancer diagnosis, death, or 1 February 2016. Smoking status was defined as ex-smoker, current smoker, and never smoker. Adjusted incidence rate ratios (aIRRs) were calculated using Poisson regression, adjusting for demographic and clinical factors. Results: In total 35442 persons from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study contributed 309803 person-years of follow-up. At baseline, 49% were current smokers, 21% were ex-smokers, and 30% had never smoked. Incidence of all cancers combined (n = 2183) was highest <1 year after smoking cessation compared to never smokers (aIRR, 1.66 [95% confidence interval {CI}, 1.37-2.02]) and not significantly different from never smokers 1-1.9 years after cessation. Lung cancer incidence (n = 271) was elevated <1 year after cessation (aIRR, 19.08 [95% CI, 8.10-44.95]) and remained 8-fold higher 5 years after smoking cessation (aIRR, 8.69 [95% CI, 3.40-22.18]). Incidence of other smoking-related cancers (n = 622) was elevated in the first year after cessation (aIRR, 2.06 [95% CI, 1.42-2.99]) and declined to a level similar to nonsmokers thereafter. Conclusions: Lung cancer incidence in HIV-infected individuals remained elevated >5 years after smoking cessation. Deterring uptake of smoking and smoking cessation efforts should be prioritised to reduce future cancer risk.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciy508
Authors: Leah Shepherd, Lene Ryom, Matthew Law, Kathy Petoumenos, Camilla Ingrid Hatleberg, Antonella d’Arminio Monforte, Caroline Sabin, Mark Bower, Fabrice Bonnet, Peter Reiss, Stephane de Wit, Christian Pradier, Rainer Weber, Wafaa el-Sadr, Jens Lundgren, Amanda Mocroft, Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group
Institutions: University College London, University of Copenhagen, Rigshospitalet, Centre of Excellence for Health, Immunity and Infections, UNSW Sydney, Kirby Institute, Ospedale San Paolo, Chelsea and Westminster Hospital, Université de Bordeaux, Inserm, Centre Hospitalier Universitaire de Bordeaux, Amsterdam UMC Location University of Amsterdam, Stichting HIV Monitoring, University of Amsterdam, Université Libre de Bruxelles, Centre Hospitalier Universitaire de Saint-Pierre, Centre Hospitalier Universitaire de Nice, University of Zurich, University Hospital Zurich, Columbia University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2808469378