Work

Inducible costimulator is essential for collagen-induced arthritis

Year: 2003

Type: article

Abstract: CD4 + helper Th cells play a major role in the pathogenesis of rheumatoid arthritis.Th cell activation, differentiation, and immune function are regulated by costimulatory molecules.Inducible costimulator (ICOS) is a novel costimulatory receptor expressed on activated T cells.We, as well as others, recently demonstrated its importance in Th2 cytokine expression and Ab class switching by B cells.In this study, we examined the role of ICOS in rheumatoid arthritis using a collagen-induced arthritis model.We found that ICOS knockout mice on the DBA/1 background were completely resistant to collagen-induced arthritis and exhibited absence of joint tissue inflammation.These mice, when immunized with collagen, exhibited reduced anti-collagen IgM Ab's in the initial stage and IgG2a Ab's at the effector phase of collagen-induced arthritis.Furthermore, ICOS regulates the in vitro and in vivo expression of IL-17, a proinflammatory cytokine implicated in rheumatoid arthritis.These data indicate that ICOS is essential for collagen-induced arthritis and may suggest novel means for treating patients with rheumatoid arthritis.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci200317321

Authors: Roza I. Nurieva, Piper Treuting, Julie Duong, Richard A. Flavell, Chen Dong

Institutions: University of Washington, Howard Hughes Medical Institute, Yale University

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Howard Hughes Medical Institute, Arthritis Foundation, University of Washington