Work

The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes

Year: 2018

Type: review

Abstract: PURPOSE OF REVIEW: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). RECENT FINDINGS: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function. The intestinal microbiota is known to be associated with metabolic syndrome and related comorbidities. Associated diseases including obesity, T2D, and fatty liver disease (NAFLD/NASH) all seem to be linked to altered microbial composition; however, causality has not been proven yet. Elucidating the potential causal and personalized role of the human gut microbiota in obesity and T2D is highly prioritized.

Source: Current Diabetes Reports

DOI: 10.1007/s11892-018-1020-6

Authors: Ömrüm Aydin, Max Nieuwdorp, Victor Gerdes

Institutions: Slotervaartziekenhuis, Amsterdam UMC Location University of Amsterdam, University of Gothenburg, Amsterdam UMC Location Vrije Universiteit Amsterdam

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,890